With a POD no later than 1503, have Cesare Borgia unite, at the least, from the Alps to the boot's tip by 1520 under either his personal rule or that of a Borgia-friendly Pope.
For bonus points, have him conquer Sardinia and Sicily as well.
For extra bonus points, do it before his OTL death (1507).
For bonus points, have him conquer Sardinia and Sicily as well.
For extra bonus points, do it before his OTL death (1507).