With no PoDs prior to 1833, how can the OTL defeat and humiliation of Qing China in the First Opium War he prevented or, failing that, curbed as much as possible? If, for example, this involves delaying an equivalent conflict,* how can China plausibly come to utilize the extra time as needed? And once we have a plausible scenario, how does this subsequently change Chinese and world history?
*and to be clear, if the conflict between Britain or another European power is delayed, but the Qing are still defeated as badly or worse, that does not meet the OP