As with so many AH scenarios, the problem with instituting a "Grand Dérangement" in Quebec is logistics. Simply put there were a hell of a lot more people in Quebec than in Acadia and to move said people would've been very costly and frankly almost impossible.
That being said, provided one utilizes an early enough POD this becomes more plausible. Ideally you'd want the British to conquer Quebec fairly early on, before the population really takes off as to make Anglicization easier. Now, with a POD after 1750 that becomes a bit harder as by this point Quebec's population is already quite large.
Perhaps with a POD in the 7 years war, with Braddock somehow winning the Battle of the Monongahela in 1755 and France not reinforcing Quebec, leading to a much earlier British conquest of the region perhaps in 1756. For the next 5 years the French colonists and the (mainly American) occupying forces fight a simmering guerilla war in which the British employ draconian tactics to gain the upper hand. This, coupled with harsh winters and poor harvests might be enough to severely whittle down the French population.
Add to this a more competent, less pragmatic treatment of Quebec following the war and perhaps British anglicization efforts could stand a chance of succeeding.