But really, the French, the Spanish and any other rival to the Portuguese-English-Dutch tag-team are going to have massive freak-outs. That is the strongest block in Europe since the Habsburgs borderline took over Western and Central Europe back when. English + Portuguese + Dutch fleets mean they have total control of the North Sea, with the possibility of having huge fleets that pretty much control the entire Atlantic and blow anything from the French and the Spanish (not to mention Swedes, Danes and whatever other players) that decides to exit from the other side of Gibraltar.
The piracy against the French and the Spanish will reach epic levels.
On the other hand, the French and Spanish can attack Portugal and the Netherlands by land.
They also have pretty much full control of the slave trade, and English + Portuguese + Dutch team-up sound like the death kneel of Indian Independence, as well as Indonesian.
Could they together lock down the Spice Market and create a Venetian-tier market domination in the spice market?
I suspect the French will bring the Ottomans to their side, get someone to lock down the Mediterranean for them. Ottomans will gladly go because they didn't like Europeans meddling in India, either. Austria goes to the other side? And I have no idea what the Swedes will do.