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I was recently read on the Cretan Revolts on the 1800's and discovered an interesting note on the third revolt;
"At this time, the Americans tried to establish a presence in the Mediterranean and showed support for Crete. The relationship grew as they looked for a port in the Mediterranean and they thought, among others, to buy the island of Milo or Port Island."
I thought this could provide an interesting POD and wanted to see what people more knowledgeable in the region might think