Butterfly away the collapse of Alexander's empire and you butterfly away Pyrrhus and the havoc he created in Magna Graecia. Now, you might have someone else come-the Tarentines and, eventually (due to their trouble with the Mamertines) the Syracusans, will still petition for assistance-but things still change massively. Assuming for whatever reason everyone is tied up in the east and no assistance can come to the Tarentines, they won't survive long. The Syracusans will struggle mightily with the Mamertines. The Carthaginians, not having to deal with Pyrrhus in the intervening years, might very well take Messana themselves early. Who knows, there's even a chance they could take Syracuse.
In any case, assuming Carthage has Messana, that removes any reason for Rome to be brought into the affairs in Sicily. If Syracuse is ever desperate enough, they will always petition a Greek power in the east for help, never the Romans. So the Romans don't necessarily have any casus belli to invade Sicily. They might remain, at least for a while longer, a purely land power, and focus on the Po Valley much earlier and with more devoted attention.