On September 6, 2007, Israeli fighter jets attacked and bombed a northern Syrian complex near Dayr al-Zawr which was suspected of holding nuclear materials that Syria had obtained from North Korea. In this challenge, the Israelis are successful in destroying their target, but three F-15s are shot down and their pilots are captured.
From this point on, your challenge is to create the worst possible scenario for Israel and the Arab world as a whole. My best idea would be to have Israel invade Syria in order to secure the release of the pilots, which ends in Syria using chemical weapons against Israeli targets.