1220 -- Pisa/ Sicily war
Due to Pisan support of Byzantine, Bah... Bah... The Rogers of Sicily gain control of Pisa, along with Sardinia, Corsica, the Balearic's & Carthage.
OTL Pisa did control them at this time
1268 -- Sicilian/ Genoa War [OTL it was with Pisa] over control of Sardinia, Corsica, and the Balearic's.
With control over Genoa, The 2 Sicily's control the West coast of Italy except for the Papal States. While the East coast is split between Sicily and Venice.
1300's
Sicily works at expanding it's holdings in Tunisia, this brings Italian Merchants and Power into Egypt, and Morocco as the other two terminus's of the trans Sahara/Africa trade.
1400's
Fall of Constantinople, brings Sicily and Venice into Alliance, to protect their Egyptian trade.
Sicilian/Argon War over the Western Mediterranean.
1500's
As Portugal begins it's expansion around Africa to East Asia, Sicily and Venice cooperate on Building a Med/Red sea canal.
1600's
Italy under the Two Sicily's, competes with Portugal in East Africa, and the Indian Ocean.