Ignoring overall outcome for Germany, and just hurting the Soviets any manner possible?
Immediately after Manstein's backhand blow, begin fortification of Panther Wotan.
It will be breached, and this must be accepted. Secondary and tertiary lines must be established 50 and 100km behind the main lines. They will also be breached, but that's okay, they just need to buy time.
After Panther-Wotan is sufficiently fortified, begin preparing your next stronghold on the Vistula, and in the Carpathians. Powerful mobile groups will need to in place to counter breakthroughs near Lvov in Poland, and Galati in Romania, and will need the most extensive heavy construction, but the riverine and mountain passes should not be neglected either.
After both lines are sufficiently fortified, construction on your third stronghold along the Oder, and down to the Australian Alps. This will be your shortest and last line of defense. Fortification should ideally extend 100km by the time occupation of the position is necessary, but time constraints may make this infeasible.
Field armies are to make fighting withdrawals to the next defensive line once the current position becomes eminently untenable. Counter-attacks should be limited only for the purposes of closing small breaches, recapturing fortification, and rescue of troops in danger of isolation and destruction.
Survival of corps and higher formations as cohesive forces is paramount, and any sacrifice must be made to achieve this. Strategic retreat, even if abandoning extensive works and equipment, is preferable to destruction of a formation.
Herresgruppe Afrika must be withdrawn immediately. Panzer formations are to withdraw to France for a strategic reserve, and training of new units.
Panzer-lehr must never be used as a field unit.
Infantry and air components of Herresgruppe Afrika will bolster Italian defense in the Mediterranean.
Once the PAW 800 is conceived, throw as much money at it as you need. But your army needs mobility and longer range than the Panzershrecks.
Heavy tank destroyers, including the Jagdpanther, should be cut in favor of light waffentragers, and half-track mounted weapons.
Armor on the Panzer IV needs to be updated. Remove the stepped plating, and form a contiguous sloped glacis plate.
For the love of God, beef up the Panther's drive train.
Only Bf 109's, Fw 190's, ju 52s, and Ju-188's should be built. Any lines not capable of subassembly or construction for these modes should be converted to any possible war production.
Copy the God damn magnetron.
Killing Soviets is your number one goal. Germany did a hell of a job OTL, just stretch it out as long as possible or until Instant Sunshine comes into play. Whichever comes first.