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Is part of the reason the South American natives survived longer on a large scale (as a distinct genetic group/culture) because they interbred with their conquerors, and thus got a genetic resistance to the European diseases? You can make fun of if I'm horribly wrong.

I know that the Plains Amerindians survived longer too, but didn't they breed a lot with Europeans?

I'm trying to think of a PoD that changes the cliche of "Native Americans get immunity to European diseases", and that's the only one I can think of.
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