AANW WI: the Nazis discover nuclear weapons are possible?

What if in the Anglo American Nazi War TL Nazi Germany somehow in the mid 1940s discovers that nuclear weapons are possible (despite KGB efforts to convince them otherwise) and attempt to build their own?

How many could they plausibly build with the resources of Europe and what yields would they be?

How would this affect the Reich's relationship with the UK and US?

Would the St. Patrick's Day Raid be a nuclear attack as opposed to conventional munitions?
 
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They have a late start, so I expect them to have less bombs than the Allies. However the scary part is that since they have the edge on rocket technology, they might devote resources to miniaturization and nuclear ballistic missiles. It is very possible that at some point when the war resumes, they will launch ICBMs against England and Atlantic bases, if not against the US itself.
 
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