A wife for Edmund Tudor, 1st Duke of Somerset.

Who is the most likely bride for a surviving Edmund Tudor in between 1515 - 1521 timeframe? My guess would be Isabella of Portugal, the wife of OTL Charles V, Holy Roman Emperor. Please discuss!
 
To whom will OTL Holy Roman Emperor Charles V be married ITTL? Also even if Charles wouldn't be elected Holy Roman Emperor, he would still be king of Castille, heir to the kingdom of Aragon etc., archduke of Austria, duke of Burgundy (and 'sovereign lord' of the Netherlands) etc.; in short a much better match than Edmund Tudor.

OTOH Isabella wasn't the first choice for a bride for OTL Charles V, Mary Tudor, the sister of Arthur Tudor and Henry VIII (due to the young of his (Henry VIII) daughter Mary, she never was a serious option, since Charles needed an heir and couldn't afford to wait) was .
 
That really depends on the PoD, if not much changes ITTL and the Portuguese court will have to choose between Charles and Edmund, then Charles would be the preferred choice.
However if for instance Charles V and Mary Tudor (IOTL queen consort of France) would marry, then Edmund and Isabella could happen.

However if that doesn't happen, then a younger sister of Isabella, like Beatrice might be an option. IOTL she married the duke of Savoy and though that wasn't an unimportant medium power, a match with Edmund could further Anglo-Portuguese relations.
A bit more unlikely could be that Edmund might become the second husband of one of Charles V' widowed sisters.
 
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