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Out of curiosity, OTL Juan of Aragon, Prince de los Asturias' child by Margarethe of Austria was a stillborn daughter; if the POD were to be that the daughter survives instead of Juan, might she marry a Trastamara from Naples? Enrique II of Navarra? The future Karl V? Joao III of Portugal? Francois I of France?

An interesting twist would be a marriage between this daughter, call her Isabel II, and Francois (since France was a traditional ally of Castile) and seeing a much earlier War of the Spanish Succession. This would leave Anne de Bretagne's proposed marriage of her daughter Claude to Karl V possible (if unlikely). Isabella of Portugal would be the loser unless she gets fobbed off with Ferdinand I, (also unlikely since Anne of Bohemia was a better candidate) or maybe her half-uncle, Juan of Girona, Germaine de Foix's son who might or might not exist. Depends how Fernando of Aragon would take to a granddaughter.
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