A different Portuguese led Iberian union.

Miguel Da Paz, prince of Portugal was born 23 August 1498 to Manuel I of Portugal and Iseballa of Aragon the eldest daughter of the catholic monarchs. For the near two years he was alive he was accepted as heir to Portugal, Castillo and Aragon, but he died aged 1 year and 329 days.

So WI he had survived to adulthood, had many children and inherited all 3 kingdoms. How would this have effected Europe and the new world?
 
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