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Hi. Well, I know the tv show "Reign" is wholly unnacurate, but watching it gave an idea:
Catherine de' Medici was unnable to get pregnant for ten years. There was even talk of repudiating her, and Diane de Poitiers made sure that Henry bedded his wife (because aparently she approved of Catherine), but...

Diane's husband, Louis de Brézé, died in 1531. So she was a widow, and still could remarry because we're not in 1560 yet.

It's believed Diane became Henry's mistress in 1534, a mere year after his marriage with Catherine, which as we all know, wasn't really favoured in the french court, by how the Medicis were considered (nothing more than upstarts).

And yeah, Diane's feelings towards Catherine aside, what if she had given Henry a male child in 1536? She was 37, and clearly fertile, by the two children she had had with her husband, Françoise and Louise de Brézé.

What if, instead of birthing Francis in 1544, Catherine had had a miscarriage that almost killed her? What if Henry had considered legitimazing his bastard son, let's call him Sebastian de Poitiers? A healthy, male son of Henry II of France, while the queen has apparently great difficulty getting pregnant and has had a miscarriage that may or may not have left her unable to have more children?

He would be 6 years older than Mary, but, well, what do you think?

Also, what if Mary, Queen of Scots, hadn't been so influenced by her Guise relatives (or more clearly, if she hadn't held her mother's opinion in such a high pedestal)? Or if her half brother, protestant James had had more influence in her?
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