Changes from the last Congress' previous Senate committee leaderships:
- Calvin Bowles (D-KY) retired from Congress; Michelle Van Dorn (D-CT) took over as ranking member of the Banking, Housing and Urban Affairs Committee.
- Alan Garland (R-AL) assumed chair of a separate committee; Ann Choate (R-MS) took over as chair of the Governmental Affairs Committee.
- Clark Gibson (R-KY) term-limited by Republican caucus rules; Sorah Wheeler (R-AK) took over as chair of the Environment and Public Works Committee.
- Jim Simon (R-SD) retired from Congress; Patrick Stacy (R-TN) took over as chair of the Health, Education, Labor and Pensions (HELP) Committee.
- Patrick Stacy (R-TN) term-limited by Republican caucus rules; Clark Gibson (R-ID) took over as chair of the Energy and Natural Resources Committee.
- Robert Starkey (D-MT) retired from Congress; Hubert "Arkansas" Smith (D-AR) took over as ranking member of the Agriculture, Nutrition and Forestry Committee.
- James Taglio (R-KS) retired from Congress; Alan Garland (R-AL) took over as chair of the Budget Committee.
- In previous Congress:
- James Lancaster (R-KY) died in office; George Wirth (R-MT) took over as chair of the Select Ethics Committee.