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Let's say the 1885 Panjdeh incident of OTL leads to an actual war, pitting Britain (and Afghanistan) against the Russian Empire and their protectorates.
I don't think any other European power would join in. Bismarck, AHE or France wouldn't be thrilled with fighting the UK especially since they have no imperialist goals in Central Asia. Turkey probably knows it's too weak to take on the Russians again at this point.
So pretty much an Anglo-Russian war in Central Asia. Who wins?