charles i of spain

What if Charles I of Spain was chosen as the Holy Roman Emperor instead of Francis I of France? How would this affect the histories of both the HRE & Spain? How would Charles manage a ridiculously big domain with assorted laws, governments & customs?

What would happen if Charles and Henry formed an alliance and declared war on France? I'd imagine that England would take most of the territory they had in the days of the Angevin Empire while Charles would seek to link his Spanish territories with the HRE and make his lands more centralized.

In 1519 one of the most contested elections for Holy Roman Emperor occurred, the two main contenders were Francis I of France and Charles I of Spain and Duke of Burgundy. They both offered big bribes but Charles had the deeper pockets and it was Charles who won. But what if Charles had suffered...