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I'm specifically talking about vaccines/inoculation. Can native populations devise something like this, and would it help at all against the ravages of smallpox?

So I was reading an alternate history humor book, and one thing stood out to me. The Dutch ended up creating a speculative bubble in producing flowers, in particular the tulip. To think that stolid, industrious Dutchmen would give up their jobs to plant flower gardens somehow made me chuckle...

Is it possible for American English to become distinct from British English as a new language? What would be necessary for such a change? Is it simply too little time for a significant difference? American and English can still be mutually intelligible, but most people should agree that they...

As a counterpoint to my earlier thread, how bad could World War II get in terms of casualties, especially civilian casualties? Scenarios can include collapse of several world powers, but no complete nuclear annihilation.

How can you get it so the dynamic between Orthodox and Catholics becomes more like Sunni and Shia?

Okay, I know it's pretty far out there, but hear me out: What if a new gnostic faith emerged in the middle of the 20th century (perhaps after World War II) that expanded enough to have several well-known figures as adherents. For the purposes of this discussion let us call this hypothetical cult...

Challenge: Have a charismatic leader unite the tribes in Central Asia around a new monotheistic religion that borrows elements from Christianity and Judaism that becomes a global religion until present day. Existence/non-existence of Islam is optional, but preferably no contact before the...

Is there a way to stop them? Preferably cultural landmarks should also stay intact, as far as possible. Would an earlier adoption of the Geneva Conventions help, or would countries end up just ignoring them anyway? What would be necessary for this to happen? Does it mean there would have to be a...

How plausible would it be for a Quaker to get elected president? Is a post-1900 PoD too late, or were there enough Quakers to feasibly see them holding public office? I imagine the Quakers' non-violence and unwillingness to swear oaths might also give rise to problems. Would it be too...