alternatehistory.com

On 1518, after the death of the Queen, Henry VIII would quickly secure a marriage with Infanta Beatrice of Portugal securing another alliance with Spain, but Beatrice would not be fertile and would have only two pregnancies who would survive term and adulthood, Henry, Prince of Wales(January 1524) and Elizabeth Tudor(May 10, 1530) and she is lucky even if she only had one son but Henry would not be entertained by the fact that Queen Beatrice would not give birth to another son, but even her stepdaughter, Mary would fail to give birth to a son as well, so she was relieved by it.

The birth of her son with King Henry would be a celebration, however, what they did not know is that Henry, Prince of Wales would fail to sire a male issue, even if he married Dorothea of Denmark who was fertile when he was young.

On 1519, Charles V would marry Isabella of Portugal as he had seen that Beatrice, her younger sister had married Henry VIII to further his alliance with the English, however, the marriage would take sometime to produce a pregnancy which would produce a surviving child until a son named Philip, Prince of Asturias was born in 1527.