Massive amounts of LL, whether it went to the UK, USSR, building up the Free French etc only kicked in well after the USA was in the war and went to a war economy. Sure even if not in the war the USA needs to rearm and expand its military, even the "isolationists" were on board with that, however they were not on board with the sort of massive US government spending needed to rearm the USA and provide the massive LL that eventuated after December 7. Basically their point was that the USA ended up getting stiffed for the WWI "bill", and that basically loaning huge amounts of money to one side (which what LL was when you come down to it) meant the USA became "invested" in one side winning and might eventually be drawn in to protect the investment. This was a very common meme.
The Republicans in 1940 were still pretty viscerally anti New Deal in any respect, and were foot dragging on even US military rearmament/expansion. To a lot of Americans, still dragging out of the Depression, spending huge amounts of money on armaments to go to the Europeans, money they expect will never be repaid (or "gently used" military goods being returned), is not going to fly. IF you're going to spend that money why not on more internal improvements by the CCC, farm supports, rural electrification, and so forth. Simply expanding production in existing facilities to supply LL is going to be expensive, and the ship building facilities that Kaiser built cranking out Liberty Ships like toys (and the suppliers delivering parts) need to be built from the ground up, and where does that money come from. Sure some folks will make financial contributions like "bundles for Britain", but the significant money has to come from the US Treasury. No war, no bond drives, no price controls to counteract inflation, no increase in tax rates, etc.
As far as the atomic bomb, the UK, on its own in the middle of this war is going to have a hard time getting this done. Even if they know to go plutonium only, which is very iffy, and don't try multiple approaches, they are resource constrained not only in money and materiel, but also scientists and engineers. What they have are quite good, but the reality is that their numbers were smaller per capita in the UK and Commonwealth, and they are mostly busy doing other more urgent tasks. IMHO the UK would really have to base their Tube Alloys project in Canada, once it got beyond the paper and blackboard stage, simply to have room, electric resources, and safety. Even if the Germans knew the exact location of the Tube Alloys research center in Ontario or Alberta, what could they do. Can the UK/Commonwealth get an atomic weapon absent the US involvement and the shared Manhattan Project, yes but the late 1940s soonest. No USA means some sort of conclusion/stalemate in Europe before instant sunshine can make a contribution. BTW while the USA may start its own atomic project even if not in the war, funding and progress will be at a much lower level.
NO USA and the UK/Commonwealth can probably clear North Africa. Good odds that most of the islands in the Med end up in UK hands, at least the smaller ones, maybe Crete, and some or all of Sicily/Sardinia/Corsica. If the Germans knock Russia out (more in a moment) there is no way they can invade the continent, whether France, Norway, Italy, Greece etc. The Germans will have too big an edge and the UK advantage stops where the water ends. Even if Sicily and Sardinia go, Benny will stay in power as long as there are no enemies on the Italian boot.
Germany can't go all the way to Siberia no matter what, at least not in the 1940s. Absent the sort of massive US LL, even if there is some, the USSR simply cannot stage the offensives they did OTL. Absent the air effort over Germany, much more of the Luftwaffe is in the east, and the USSR is further handicapped by the absence of aviation gasoline from LL. At some point the USSR will need to accept the inevitable and have an armistice with lines somewhere between the Ukraine and the Urals. Leningrad will go, and if the Germans don't occupy Baku you can expect there will be mandatory petroleum shipments to Germany. Sure the Russians will want round two, and if Stalin wants to keep fighting even as the armies are simply ground down I expect sooner or later even he would have an "accident".