Joseph Stiglitz (D-IN), for Treasury 2001-2003
Barack Obama (D-IL), for AG 2006-2009
Tom Udall (D-NM), for Interior 2001-2003
Kika de la Garza (D-TX) for Agriculture
Gary Locke (D-WA), for Commerce 2005-2009
Richard Trumka (I-PA), for Labor
Charlotte Pritt (I-WV) for HHS 2003-2009...
My main point was that it's highly unlikely that Barack Obama and John McCain will have the exact same resumes they do/did in OTL, which could mean that they're both still in politics, only one is, or neither at all.