Felipe II of Spain b. 1527 m.1543 Maria Manuela of Portugal (A) b. 1527 m. 1546 Margaret of Valois (B) b. 1523
1a. Carlos, Prince of Asturias, b. 1545, d. 1568, m. 1563 Elisabeth of Valois b. 1545
1aa. Maria Manuela, b. 1564
1ab. Felipe Prospero, Prince of Asturias, b. 1566
1ac. Carlos, b. 1567, d. 1569
2b. Isabella Clara Eugenia, Infanta of Spain, b. 1548
2c. Fernando, Infante of Spain, b. 1550
2d. Diego Felix, Infante of Spain, b. 1553
2e. Catalina Micaela, Infanta of Spain, b. 1554
2f. Felipe, Infante of Spain, b. 1556, d. 1560