POD, a plague outbreak kills Cecily, Anne and Katherine of York in 1481, while Mary of York dies as per OTL. Then Elizabeth of York as well as Edward of Warwick die in 1489 (of course foul play is suspected in the latter's death), and Henry VII remarries to Margaret of Clarence, who he has children with. Henry's children with Margaret later claim the English throne and start a third phase of the Wars of the Roses in the 1510s and 1520s:
King Henry VII of England (1457-1509) M. a). Elizabeth of York (1466-1489), b). Margaret of Clarence (1473-1554), had issue
1a). King Arthur I of England “The Righteous” (1486-1546) M. Katherine of Aragon (1485-1555), had issue
2a). Princess Margaret Tudor of England (1489-1542) M. King James IV of Scotland (1473-1515) [1], had issue
3b). Prince Henry, Duke of York "The Black Pretender" (1491-1527) M. Marguerite of Angouleme (1492-1547), had issue
4b). Prince Edmund, Duke of Richmond "The Serpent" (1494-1519) [5], never married
5b). Princess Elizabeth of England (1496-1529) M. King Christian II of Denmark (1481-1558), had issue
6b). Prince Edward, Duke of Pembroke "The Loyal" (1498-1550) M. Elizabeth Grey, Viscountess Lisle (1505-1549), had issue
...
[1] Dies in a battle during the third phase of the Wars of the Roses
[2] This phases' Elizabeth Woodville.
[3] Locked up in a convent following the Arthur I's victory.
[4] An analogue of Edward, Earl of Warwick.
[5] Dies early on in the second phase
King Henry VII of England (1457-1509) M. a). Elizabeth of York (1466-1489), b). Margaret of Clarence (1473-1554), had issue
1a). King Arthur I of England “The Righteous” (1486-1546) M. Katherine of Aragon (1485-1555), had issue
1. Henry, Prince of Wales (1502-1523), never married
2. John, Prince of Wales (1505-1526), never married
3. Princess Elizabeth of England (1505-1559) M. Holy Roman Emperor Charles V (1500-1558)
4. King Arthur II of England (1508-1569) M. Catherine of Austria (1507-1572)
5. Princess Katherine of England (1511-1578) M. King James V of Scotland (1512-1567)
2a). Princess Margaret Tudor of England (1489-1542) M. King James IV of Scotland (1473-1515) [1], had issue
1. King James V of Scotland (1512-1567) M. Princess Katherine of England (1511-1578)
2. Prince Alexander, Duke of Rothesay (1514-1559) M. Lady Helen Stewart (1519-1564)
3b). Prince Henry, Duke of York "The Black Pretender" (1491-1527) M. Marguerite of Angouleme (1492-1547), had issue
1. George, Earl of Clarence (1507-1527) M. Anne Boleyn (1507-1530) [2]
2. Lady Margaret (1510-1567), became a Nun [3]
3. Lord Henry of York (1512-1556), never married [4]
4. Lady Elizabeth (1515-1534), became a Nun
4b). Prince Edmund, Duke of Richmond "The Serpent" (1494-1519) [5], never married
5b). Princess Elizabeth of England (1496-1529) M. King Christian II of Denmark (1481-1558), had issue
1. King John III of Denmark (1512-1559) M. Sibylle of Cleves (1512-1554)
2. Princess Christina of Denmark (1514-1575) M. John Frederick I, Elector of Saxony (1503-1554)
6b). Prince Edward, Duke of Pembroke "The Loyal" (1498-1550) M. Elizabeth Grey, Viscountess Lisle (1505-1549), had issue
1. Jasper, Duke of Pembroke (1521-1553) M. Gertrude Manners (1525-1567)
2. Henry, Earl of Gwynedd (1524-1549) M. Anne Talbot (1524-1598)
...
[1] Dies in a battle during the third phase of the Wars of the Roses
[2] This phases' Elizabeth Woodville.
[3] Locked up in a convent following the Arthur I's victory.
[4] An analogue of Edward, Earl of Warwick.
[5] Dies early on in the second phase
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