Ferdinand II of Aragon (b.1452, d.1516) m. Anne of Savoy, Queen of Aragon (b.1455, d.1480) had issue, second marriage to Catherine I of Navarre (b.1468, d.1517), in 1482 had issue, also had bastard issue
1a) Stillborn son (1472)
2a) Juan of Aragon (b.1474, d.1475)
3a) Ana of Aragon, Queen of Poalnd (b.1480, d.1524) m. John I Albert of Poland in 1495 (b.1459, d.1511) had issue
1b) Ferdinand, Prince of Girona and Viana, later Ferdinand III of Aragon (b.1483, d.1532) m. Giovanna I of Naples (b.1478, d.1530) had issue
2b) Juana of Aragon (b.1485, d.1485)
3b) Magdalena of Aragon, Queen of Hungary (b.1487, d.1563) m. Vladislaus II of Hungary (1456, d.1516) had issue
4b) Fadrique of Aragon (b.1489, d.1540) m. Germaine de Foix (b.1488, d.1536) had issue
5b) Alfonso of Aragon (Archbishop of Valencia) (b.1491, d.1540)
6b) Leanor of Aragon, Queen of France (b.1492, d.1551) m. Charles IX of France (b.1492, d.1546) had issue
7b) Blanca of Aragon (b.1494, d.1504)
8b) Maria of Aragon (Nun/Abbess) (b.1496, d.1535)
9b) Stillborn son (1498)
10b) Pedro of Aragon (b.1499, d.1499)
1c) Alfonso de Aragon, Archbishop of Valencia (b.1469, d.1520)
2c) Juana de Aragon, Duchess of Frias (b.1469, d.1521) m. Bernardino Fernández de Velasco, 1st Duke of Frías (b.1450, d.1512)
3c) María Esperanza de Aragon (b. 1471 , d.1543). Abbess of Santa María la Real de Las Huelgas
4c) Beatriz de Aragon (b.1500, d.1550)