If the Bubonic Plague present in Southern France in 1525 had swept through England, killing many. Two notable victims of this bout of the plague were Queen Katherine and Charles Brandon, Duke of Suffolk.
Henry VIII m. Katherine of Aragon (a), Anne Boleyn (b)
(mistresses who had children (acknowledged and unacknowledged): Bessie Blount (c), Mary Boleyn (d), Jane Seymour (e)) (1)
1a. stillborn girl (b. 1510)
2a. Henry, Duke of Cornwall (b. 1511-1511)
3a. short-lived boy (b. 1513)
4a. short-lived boy (b. 1514)
5a. Mary of England (b. 1516-1561) (2) - marries and has issue
6a. short-lived girl (b. 1518)
7c. Henry FitzRoy, Duke of Richmond and Somerset (b. 1519-1536) m. Lady Mary Howard (no issue)
8d. Catherine Carey (b. 1524-1569) m. Sir Francis Knollys (had issue)
9b. Edmund, Prince of Wales (eventually Edmund I of England) (b. 1527-1565) m. Marie of France (a) (3)
1a. Anne of England (b. 1547-1611)
2a. Henry, Prince of Wales (b. 1549-1554)
3a. stillborn girl (b. 1552)
4a. Frances of England (b. 1555-1630)
5a. Isabel of England (b. 1556-1575)
6a. Arthur, Prince of Wales (b. 1559-1614)
7a. Thomas, Duke of Pembroke (1562-1599)
10b. miscarriage (1528)
11b. Arthur, Duke of York and Suffolk (b. 1529-1581) m. Lady Jane Grey (a)
1a. Henry of York (b. 1553-1591)
2a. Eleanor of York (b. 1557-1571)
3a. Elizabeth of York (b. 1561-1564)
4a. Anne of York (b. 1562-1562)
12b. stillbirth (b. 1532)
13b. Elizabeth of England (b. 1533-1603) m. Philippe, Duke of Berry (a) (4)
1a. Henri de Valois (b. 1548-1550)
2a. Elisabeth de Valois (b. 1551-1567)
3a. Anne de Valois (b. 1553-1626)
4a. Charles de Valois (b. 1555-1630), eventually Charles X of France, m. Claude of France, Duchess of Brittany (8)
5a. Marie de Valois (b. 1558-1619)
14b. Anne of England (b. 1534-1553) m. Frederick II of Denmark and Norway (a)
1a. Frederick of Denmark (b. 1550-51)
2a. Christian of Denmark (b. 1553-1622)
15b. Margaret of England (b. 1537-1600) m. Eric XIV of Sweden (a), John III of Sweden (b) (5)
1a. Margaret of Sweden (b. 1552-1593)
2a. Anna of Sweden (b. 1553-1594)
3a. stillborn son (b. 1554)
4b. John of Sweden (b. 1557-1597)
5b. short-lived daughter (b. 1558)
6b. Gustav of Sweden (b. 1559-1610)
7b. Charles of Sweden (b. 1561-1632)
8b. Elizabeth of Sweden (b. 1562-1609)
9b. stillborn son (b. 1563)
10b. Johan of Sweden (b. 1565-1642)
11b. Cecilia of Sweden (b. 1570-1629)
16e. Edward Howard (b. 1537-1558) (6) m. Lady Lucy Sidney
17b. Henry, Duke of Bedford and King of Scots (b. 1540-1559) m. Mary, Queen of Scots (a)
1a. James, Duke of Rothesay (b. 1557-1558)
2a. Mary of Scotland (b. 1558-1601)
3a. Robert, Duke of Rothesay (b. 1560-1607), born posthumously
ADDITIONAL INFORMATION:
Mary Tudor, Queen of France (b. 1496-1544) (7) m. Louis XII of France (a), Charles Brandon, Duke of Suffolk (b) and Francis I of France (c)
1b. Henry Brandon (b.1516-1522)
2b. Frances Brandon (b. 1517-1559) m. Henry Grey, Marquess of Dorset (notably the mother of Lady Jane Grey, Duchess of York and Somerset)
3b. Eleanor Brandon (b. 1519-1547) m. Francis, Duke of Guise
4b. Henry Brandon, Earl of Lincoln (b. 1523-1534)
5c. Philippe, Duke of Berry (b. 1529-1591) m. Elizabeth of England
6c. Marie of France (b. 1530-1588) m. Edmund, Prince of Wales
7c. stillborn twin of Marie (b. 1530)
(1) I, personally, believe that there is enough evidence to support the idea of Catherine Carey being Henry VIII's illegitimate daughter, though I do not believe there is enough to suggest that Henry Carey is his son.
(2) Lived almost a decade longer due to a lack of circumstances that would lead to a decline in her health
(3) daughter of Mary Tudor, Queen of France (previously the Duchess of Suffolk) and Francis I of France. Francis' disobedience towards his treaty with the Emperor lead to a worsening in the conditions of his elder sons. Henri, Duke of Orleans died in captivity; Francis III, Duke of Brittany was eventually returned but soon died of poor health. A death which Francis blamed the Spanish King for
(4) eldest son of Francis I of France and Mary Tudor, Queen of France
(5) Eric XIV died under mysterious circumstances, with the blame placed on one of his many mistresses; Margaret's two daughters from her first marriage hold a strong resemblance to John III
(6) Lord Thomas Howard was released from the Tower of London (where he was imprisoned due to his secret marriage to Lady Margaret Douglas, which was invalidated) on the condition that he acknowledge Edward as his son and marry Lady Jane Seymour in return for his freedom and estates in the North. Edward lived longer without certain circumstances putting further stress on his health
(7) Lived longer as did not contract illness due to different circumstances
(8) Daughter of Charles IX of France (Duke of Angouleme), who survived until 1456