WI Francis Ford Coppola, instead of Keanu Reeves, casts Daniel Day-Lewis as Jonathan Harker in Bram Stoker's Dracula? (Interestingly, he and Winona Ryder, who played Mina in the aforementioned film, starred as an engaged couple in The Age of Innocence and also co-starred in the film version of The Crucible...)
IMO, Day-Lewis would do better in the role than Reeves did (it helps, of course, that he's actually British; Reeves gave up trying to do a British accent); yeah, he's in his mid-30s, but that hasn't stopped casting directors before...
And, if Day-Lewis method acts like he's done, he'll probably be remembered for giving a good performance, IMO...