The Simpsons ends after it's first season, and the Fox TV Network ends in 1994 approx.
A new network would be required.
It depends. Like I said, Fox has a terrible business model. What it all boils down to with Fox is that it got lucky in almost inconceivable ways. It's almost ASB. It has frequently gone dry spells, but it'll get that one show every few years that is a hit, and it will cling onto that for life and suck the life out of it, then throw it away, pray for the next hit, and then cling to it when it comes along. It's like a slacker who bullshits his way through high school, never being prepared but always managing to pull it out of his butt at the last minute to do a good enough job.
If you remove 'The Simpsons', you remove a major stroke of needed luck, all the while keeping Fox with it's terrible business model. So, as said, they will lean on 'Married...With Children', and throw everything show can out there to see if they work. Given their track record, most of them won't.
One thing I forgot to mention is that Fox, very shortly after 'The Simpsons' started, got into the Black and Hispanic demographic with shows about Black people or with mostly Black cast members. It put on shows like 'In Living Color' and 'Martin', and there's more but I can't recall them at the moment. Fox did very, very well with the Black and Hispanic viewership because of those shows, meaning the other networks did not do well with that viewership at all, and that viewership made Fox competitive with the other networks. I forgot about that, but Fox will find a great deal of strength in that if it goes like the OTL. I could easily see this Fox expand on that, with more Black demographic shows, possibly more Urban youth demographic shows, and possibly Hispanic shows. That could make that trend continue into today; Fox having dropped that effort many, many, many years ago, relying instead on being sleazier; something that hearkens back to 'Married...With Children'. Fox today could be somewhat of a network BET.
That would get coupled with 'Married...With Children', spinoffs and knock offs of 'Married...With Children', and whatever else Fox may try. Fox would have a much harder time with 'The Simpsons', as it was a major phenomenon which brought in a major, instant viewership which then permeated the network as a whole. It could still survive and succeed, albeit most likely different.
Another factor of course is that adult oriented animation programming does not, very likely, come about. That would have a major effect on everything because that has become a major thing. I would posit it would also have an effect on younger-than-adults animation, because that has become increasingly and refreshingly less uptight about being open. I remember when I reached about 12 I couldn't stand cartoons anymore because they just would not stop pulling punches and were increasingly getting PC, "we don't wanna hurt the children" silly; that's when I went over to live-action programming. I find shows like 'Spongebob Square Pants', 'Adventure Time', and 'Regular Show' very refreshing because they're shows that work on layers for every age and do appeal to teenagers and adults. I would go out on a limb and say that those shows were allowed to do that because you have 'Family Guy' on the air which younger people and kids do watch as much as adults, so that trend of "this may start a school shooting", "woah, let's not offend anyone" silliness in cartoon programming has been reversed. It took a while, and it wasn't done by 'The Simpsons', but 'The Simpsons' started it (you wouldn't have 'Family Guy' with it). And without 'The Simpsons' it may actually have gotten worse.
EDIT: Fox would also very much benefit from having it's affiliates pick up first-run syndicated shows, such as 'Arsenio Hall' and 'Star Trek: The Next Generation'.
"The Simpsons" is my all time favorite animation show.
I'm from Mongolia. So if Simpsons cancelled after 1st season i wouldn't have been known the Homer, Bart, Marge, Liza and my lovely Maggie. That would be sad.
We have a member from Mongolia?