WI No Thanksgiving

In honor of this American Thanksgiving, let's explore some possibilities:

What would have happened if the Natives didn't help the Plymouth settlers that first season? Would they have starved and the colony failed? If so, how would that have affected colonisation patterns in the new world and the development of the 13 colonies? Would more religious...let's say hardliners (for the sake of holiday spirits) stay in England and what would be the affect there?

If the Wampanoag are still struck by that epidemic and choose the most idiotic of options to exterminate the Pilgrims, the Pilgrims lose, then the Narragansett and other enemies thrash the Wampanoag.

Without an epidemic, the Pilgrims lose without any real issue for the Indians.

Considering the modern conception of the First Thanksgiving as we know it dates largely from the 19th century, then no Thanksgiving would be no big deal in the US. Had it been timed with the traditional European harvest festival, however (like Canada), it would be different. That's not to say that the First Thanksgiving did not happen - something like it probably did happen, but not in the way modern culture interprets it.

One of the major problems the Pilgrims had was that the crop seeds they brought from England were not usable long-term in the soil where they landed. They could probably last a few years on hunting, fishing and some farming but I doubt they'd last more than 5 years before they decided enough was enough.