Wasn't there some kind of rule saying that the German Confederation states had to be Semi-Salic? There was definitely something of the sort under the Empire, during the Lippe succession thing, which went to Imperial arbitration. Anyway, if so, all we need is Victoria being male or dying young. If she is succeeded by Ernst August of Hannover, that has implications for Britain - some melodramatic people say that the Chartists would overthrow the monarchy in 1848, for instance.
If Hannover joins the German Empire, that would put the British monarchy in a similar position as they were in as Dukes of Normandy and Aquitaine, etc. which ended quite badly for them. Therefore, Victor or whoever would be more likely to stay out of the the North German Confederation and the Empire, perhaps prompting an Anglo-Prussian War in the 60s or 70s, but I don't think even Prussia would dare pissing off all of their neighbours and taking on the biggest empire in the world. That said, would the British parliament necessarily go to war over Hannover?
Also, Hannover is hardly in the middle of the prospective German nation: the only places that would be cut off would be the Grand Duchy of Oldenburg and the Free City of Bremen - Bismarck may just cut his losses if that's the only reward for a possible war against the UK (especially a UK with a bridgehead on the Continent).