POD: 1787
The baby known as Shaka Zulu OTL dies in childbirth along with his mother.
Effects, anyone?
Well, the Zulus could end up (due to fragmentation) as part of the other two "empires" in South Africa at the time - either Moshoeshoe and the Basotho, or Mzilikazi's "state" up north of the Ndebele. Unless they can make nice with the Xhosa to the south (which they still aren't able to) and join up with them against the settlers.